Zytiga: Uses, Dosage, Side Effects

Zytiga: Uses, Dosage, Side Effects
Zytiga

Abiraterone acetate, the active ingredient of ZYTIGA is that the acyl organic compound of abiraterone. Abiraterone is AN matter of CYP17 (17α-hydroxylase/C17,20-lyase). every ZYTIGA pill contains either 250 mg or five hundred mg of abiraterone acetate. Abiraterone acetate is selected with chemicals as (3β)-17-(3-pyridinyl) androsta-5,16-dien-3-yl acetate.

Abiraterone acetate could be a white to off-white, non-hygroscopic, crystalline powder. Its formula is C26H33NO2 and it's a mass of 391.55. Abiraterone acetate could be a oleophilic compound with AN octanol-water partition constant of five.12 (Log P) and is much insoluble in water. The pKa of the aromatic N is five.19.

ZYTIGA tablets are out there in five hundred mg film-coated tablets, 250 mg film-coated tablets and 250 mg uncoated tablets with the subsequent inactive ingredients:

500 mg film-coated tablets: mixture oxide, croscarmellose metallic element, hypromellose, milk sugar hydrate, Mg stearate, silicified crystalline polyose, and metallic element lauryl salt. The coating, Opadry II Purple, contains iron compound black, iron compound red, polythene glycol, polyvinyl alcohol, talc, and titania.
250 mg film-coated tablets: mixture oxide, croscarmellose metallic element, milk sugar hydrate, Mg stearate, crystalline polyose, povidone, and metallic element lauryl salt. The coating, Opadry II Beige, contains iron compound red, iron compound yellow, polythene glycol, polyvinyl alcohol, talc, and titania.
250 mg uncoated tablets: mixture oxide, croscarmellose metallic element, milk sugar hydrate, Mg stearate, crystalline polyose, povidone, and metallic element lauryl salt.

 

Generic Name: abiraterone acetate tablets

 

Zytiga Indications:

ZYTIGA is indicated together with glucocorticoid for the treatment of patients with

Metastatic castration-resistant prostatic adenocarcinoma (CRPC)
Metastatic speculative castration-sensitive prostatic adenocarcinoma (CSPC)

 

Zytiga Dosage:

Recommended Dose For pathological process CRPC
The counseled dose of ZYTIGA is one,000 mg (two five hundred mg tablets or four 250 mg tablets) orally once daily with Liquid Pred five mg orally doubly daily.

Recommended Dose For pathological process unsound CSPC
The counseled dose of ZYTIGA is one,000 mg (two five hundred mg tablets or four 250 mg tablets) orally once daily with Liquid Pred five mg administered orally once daily.

 

Zytiga Side Effects:

The following are mentioned in additional detail in different sections of the labeling:

Hypertension, symptom, and Fluid Retention thanks to adrenal cortical steroid Excess.
Adrenocortical Insufficiency.
Hepatotoxicity.

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